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FLASH GENE
Symbol KCNG3 contributors: mct - updated : 24-06-2014
HGNC name potassium voltage-gated channel, subfamily G, member 3
HGNC id 18306
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3824 49.6 436 highly in brain,pancreas,testis lowly in lung,kidney,thymus,ovary,small intestine and colon Ottschytsch,Sano
- - 3791 - 425 - Ottschytsch,Sano
lacking an internal segment
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal cytoplasmic domain
  • six transmembrane domains,the fourth being probably the voltage sensor
  • a pore forming domain between the fifth and sixth transmembrane domains
    • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Kcng3
    Homologene
    FAMILY
  • potassium channel family, G subfamily
    • CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • potassium channel subunit modulating channel activity
  • mediating the voltage-dependent potassium ion permeability of excitable membranes.
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
  • forming potassium channels only if heteromultimerized
  • KCNB1 or KCNC1 or KCNF1
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by BMP2 that significantly (>2-fold) upregulated mRNA expression of KCNG3
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS