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FLASH GENE

Symbol

ITGA8

contributors: mct - updated : 11-03-2016

HGNC name	integrin, alpha 8
HGNC id	6144

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

BRA1

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   associated with increased cardiac interstitial fibrosis tumoral     --low   by aberrant promoter methylation in ovarian cancers (Cai 2007) constitutional germinal mutation       in isolated Congenital anomalies of the kidney and urinary tract (CAKUT)

Susceptibility

to hypertrophic cardiomyopathy to modification of the progression of renal failure in autosomal-dominant polycystic kidney disease (ADPK

Variant & Polymorphism other	modifier gene of MYBPC3, in hypertrophic cardiomyopathy
	polymorphism of the ITGA8 promoter modifies the progression of renal failure in ADPKD

Candidate gene
Marker	ITGA2B, ITGA8, GIT1, and SHC1 were identified as independent prognostic factors of overall survival of clear cell renal cell carcinoma
Therapy target

ANIMAL & CELL MODELS

mice deficient for ITGA8 have structural alterations in glomeruli but not in renal arteries