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FLASH GENE
Symbol ITGA8 contributors: mct - updated : 11-03-2016
HGNC name integrin, alpha 8
HGNC id 6144
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular heavy chain with seven FG-GAP repeats
  • 13 N-glycosylation sites
  • three calcium binding sites, a cell attachment site, linked by a disulfide bond to a light chain with an extracellular domain with two N-glycosylation sites
  • a transmembrane and a cytoplasmic domain
    • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Itga8
    homolog to rattus Rn.69726
    homolog to Drosophila scb
    homolog to C.elegans F54F2.1
    Homologene
    FAMILY integrin alpha chain family
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in cell-cell adhesion and cell- matrix adhesion
  • implicated in cardiac fibrosis
  • the influence of ITGA8 on the expression of matrix components was not uniform and celltype dependent, and seems unlikely to exert overall profibrotic effects in renal cells
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    text kidney morphogenesis
    PATHWAY
    metabolism
    signaling
    a component ITGA8 and ITGB1
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to fibronectin (FN1), vitronectin, tenascin (by their RGD sites)
    cell & other
    REGULATION
    induced by in response to pro-hypertrophic and pro-fibrotic agent angiotensin II
    ASSOCIATED DISORDERS
    corresponding disease(s) BRA1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    associated with increased cardiac interstitial fibrosis
    tumoral     --low  
    by aberrant promoter methylation in ovarian cancers (Cai 2007)
    constitutional germinal mutation      
    in isolated Congenital anomalies of the kidney and urinary tract (CAKUT)
    Susceptibility
  • to hypertrophic cardiomyopathy
  • to modification of the progression of renal failure in autosomal-dominant polycystic kidney disease (ADPK
    • Variant & Polymorphism other
  • modifier gene of MYBPC3, in hypertrophic cardiomyopathy
  • polymorphism of the ITGA8 promoter modifies the progression of renal failure in ADPKD
    • Candidate gene
    Marker
  • ITGA2B, ITGA8, GIT1, and SHC1 were identified as independent prognostic factors of overall survival of clear cell renal cell carcinoma
    • Therapy target
    ANIMAL & CELL MODELS
  • mice deficient for ITGA8 have structural alterations in glomeruli but not in renal arteries