Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | ITGA8 | contributors: mct - updated : 11-03-2016 |
HGNC name | integrin, alpha 8 |
HGNC id | 6144 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 202.00 kb 30 Exon(s) |
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10 Kb 5' upstream gene genomic sequence study |
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regulatory sequence | Promoter |
text structure | ![]() |
MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | restricted |
tissue |
|
cells |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
physiological period | embryo |
Text | developing kidney |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
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conjugated | GlycoP |
mono polymer | heteromer , dimer |
isoforms | Precursor |
HOMOLOGY |
interspecies | ortholog to murine Itga8 |
homolog to rattus Rn.69726 | |
homolog to Drosophila scb | |
homolog to C.elegans F54F2.1 |
Homologene |
FAMILY | integrin alpha chain family |
CATEGORY | adhesion , structural protein |
SUBCELLULAR LOCALIZATION
| plasma membrane |
basic FUNCTION | |
| |
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CELLULAR PROCESS | cell communication |
PHYSIOLOGICAL PROCESS | development |
text | kidney morphogenesis |
PATHWAY |
metabolism |
signaling |
a component | ITGA8 and ITGB1 |
INTERACTION |
DNA |
RNA |
small molecule |
protein | binding to fibronectin (FN1), vitronectin, tenascin (by their RGD sites) |
cell & other |
REGULATION |
induced by | in response to pro-hypertrophic and pro-fibrotic agent angiotensin II |
ASSOCIATED DISORDERS |
corresponding disease(s) | BRA1 |
Other morbid association(s) |
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Susceptibility |
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Variant & Polymorphism other | |
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Candidate gene
Marker
| ![]() Therapy target
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ANIMAL & CELL MODELS |
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