SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,cytoplasm,cytoskeleton,microtubule
|
text
| predominantly located to the Golgi |
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localizes predominantly to the primary cilium during interphase |
basic FUNCTION
| cleaving the N terminal transit peptide from mitochondrial protein precursors |
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may hydrolyzes phosphatidylinositol 3,4, 5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby may regulate Golgi-vesicular trafficking |
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with INPP5D and INPP5K, implicated in negatively regulating insulin signalling and glucose homoeostasis in specific tissues |
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regulate macrophage phagocytosis |
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plays an essential role in the primary cilium by controlling ciliary growth factor and PI3K signaling and stability |
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functions to stabilize the normal structure and number of primary cilia in quiescent cells stimulated by growth factors |
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regulates cilia stability |