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FLASH GENE
Symbol IL17D contributors: - updated : 30-07-2003
HGNC name interleukin 17D
HGNC id 5984
Location 13q12.11      Physical location : 21.277.481 - 21.297.236
Genatlas name interleukin 17D resting CD4+ T-cells, resting CD19+ B-cells
Synonym name interleukin 27
Synonym symbol(s) IL27, IL-22, IL-27, IL-17D
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
HSMPP8 13q12.11 M-phase phosphoprotein, mpp8 PSPC1 13q12-11 paraspeckle component 1 LOC390377 13 similar to Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide alpha-2,6-sialyltransferase (NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase) (ST6GalNAc IV) (Sialyltransferase 7D) (Sialyltransfer ZNF237 13q11-q12 zinc finger protein 237 LOC387901 13 LOC387901 ZNF198 13q11-q12 zinc finger protein 198 LOC144845 13q12.11 hypothetical protein BC008631 GJA3 13q11 gap junction protein, alpha 3, 46kDa (connexin 46) LOC390378 13 similar to peptidylprolyl isomerase A GJB2 13q11-q12.1 gap junction protein, beta 2, 26kDa (connexin 26) GJB6 13q12.1 gap junction protein, beta 6 (connexin 30) CRYL1 13q11 crystallin, lambda 1 TG737 13q12.1 crystallin, lambda 1 IL17D 13q12.11 interleukin 17D LOC221143 13q12.11 hypothetical protein LOC221143 XPO4 13q11 exportin 4 LOC390379 13 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) LOC387902 13 similar to protein 40kD LATS2 13q11-q12 LATS, large tumor suppressor, homolog 2 (Drosophila) LOC338870 13q12.11 similar to ribosomal protein S12 LOC390380 13 similar to chromosome 9 open reading frame 12; 1,3,4,5,6-pentakisphosphate 2-kinase SAP18 13q12.11 sin3-associated polypeptide, 18kDa C13orf3 13q11 chromosome 13 open reading frame 3 MRP63 13p11.1-q11 mitochondrial ribosomal protein 63 LOC387903 13 LOC387903 ESTRRA 13q12.11 estrogen-related receptor alpha pseudogene LOC387904 13 similar to hypothetical protein GPRK6P 13pter-q21 G protein-coupled receptor kinase 6 pseudogene LOC387905 13 LOC387905 FLJ25952 13q12.11 hypothetical protein FLJ25952 LOC387906 13 similar to RIKEN cDNA 5033406L14 LOC390382 13 similar to histone 1, H2bc; H2B histone family, member S FLJ34588 13q12.11 Smhs2 homolog (rat) LOC387907 13 similar to bA271B5.1 (similar to ribosomal protein S7) FGF9 13q11-q12 fibroblast growth factor 9 (glia-activating factor)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Lymphoid/Immunespleen    
Nervousbrain    
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectiveadipose   
Epithelialsecretoryglandularendocrine 
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Lymphoid/Immuneactivated B lymphocyte
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide
  • an homodimerization motif with conserved cysteines
  • an unique extended C-terminal domain
  • mono polymer homomer , monomer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine Il17d
    intraspecies homolog to IL17
    Homologene
    FAMILY IL17 family
    CATEGORY secretory , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • regulating cytokine production in endothelial cells
  • inhibiting hemopoiesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS