SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
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| localizes to late endosomes, where reoviruses undergo proteolytic disassembly |
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localizes to endolysosomes where it prevents virus fusion |
basic FUNCTION
| involved in antiviral response |
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IFITM1, IFITM2, IFITM3 mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus |
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IFITM1, IFITM2, IFITM3 are important components of the innate immune system to restrict HIV-1 infection |
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act as antiviral restriction factor |
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suppress cellular and HCV IRES-mediated translation |
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IFITM1, IFITM2, IFITM3 are potentially involved in the differentiation and cell proliferation during heart development |
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is essential for defending the host against influenza A virus |
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acts as an essential barrier to influenza A virus infection, and plays a pivotal role in defence against influenza virus infections |
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can inhibit viruses that enter cells via different routes and its N-terminal region is specifically required for controlling pH-dependent viruses |
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restricts infection by a nonenveloped virus and suggest that IFITM3 targets an increasing number of viruses through a shared requirement for endosomes during cell entry |
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essential for innate defense against influenza virus in humans |
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role of IFITM3 in the pathogenesis of neurodevelopmental diseases associated with immune activation |
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is a cellular endosome- and lysosome-localized protein that restricts numerous virus infections |
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IFITM3 can play an important role in regulating inflammation balance |