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FLASH GENE
Symbol HYOU1 contributors: - updated : 09-01-2006
HGNC name hypoxia up-regulated 1
HGNC id 16931
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal domain
  • a chain with ATP binding sites
  • nine glycosylation sites
  • one site preventing secretion from endoplasmic reticulum
    • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to Drosophila EG:25E8.1
    homolog to C.elegans T14G8.3
    Homologene
    FAMILY heat shock protein 70 family
    CATEGORY chaperone/stress , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • having a cytoprotective role in hypoxia-induced cellular perturbations
    • CELLULAR PROCESS cell life, antiapoptosis
    protein, post translation, folding
    protein, post translation, targeting
    PHYSIOLOGICAL PROCESS nervous system
    text wound healing
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
    cell & other
    REGULATION
    induced by hypoxia,tunicamycin,2-desoxyglucose,oxidized LDL
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in atherosclerotic plaques
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS