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FLASH GENE

Symbol

HYOU1

contributors: - updated : 09-01-2006

HGNC name	hypoxia up-regulated 1
HGNC id	16931

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessels aorta

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth       Muscular striatum cardiac     Muscular striatum skeletal     Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage Nervous astrocyte

cell lineage
cell lines	breast cancer, thyroid carcinoma, pancreatic carcinoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal domain
	a chain with ATP binding sites
	nine glycosylation sites
	one site preventing secretion from endoplasmic reticulum

conjugated

GlycoP

isoforms

Precursor

HOMOLOGY

interspecies	homolog to Drosophila EG:25E8.1
	homolog to C.elegans T14G8.3

Homologene

FAMILY

heat shock protein 70 family

CATEGORY

chaperone/stress , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic

basic FUNCTION

having a cytoprotective role in hypoxia-induced cellular perturbations

CELLULAR PROCESS	cell life, antiapoptosis
	protein, post translation, folding
	protein, post translation, targeting

PHYSIOLOGICAL PROCESS

nervous system

text	wound healing

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein

cell & other

REGULATION

induced by

hypoxia,tunicamycin,2-desoxyglucose,oxidized LDL

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in atherosclerotic plaques

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS