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FLASH GENE

Symbol

HYOU1

contributors: - updated : 09-01-2006

HGNC name	hypoxia up-regulated 1
HGNC id	16931

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q23.1-q23.3      Physical location : 118.914.895 - 118.927.925
Synonym name	oxygen regulated protein (150kD)
Synonym symbol(s)	ORP150

DNA

TYPE	functioning gene
STRUCTURE	13.00 kb     27 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (CAAT box)
	cytosine-phosphate-guanine/HTF
	Binding site   transcription factor
text structure	Sp1 binding sites
	ERSE like sequence

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessels aorta

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular smooth       Muscular striatum cardiac     Muscular striatum skeletal     Nervous central

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage Nervous astrocyte

cell lineage
cell lines	breast cancer, thyroid carcinoma, pancreatic carcinoma
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal domain
	a chain with ATP binding sites
	nine glycosylation sites
	one site preventing secretion from endoplasmic reticulum

conjugated

GlycoP

isoforms

Precursor

HOMOLOGY

interspecies	homolog to Drosophila EG:25E8.1
	homolog to C.elegans T14G8.3

Homologene

FAMILY

heat shock protein 70 family

CATEGORY

chaperone/stress , protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic

basic FUNCTION

having a cytoprotective role in hypoxia-induced cellular perturbations

CELLULAR PROCESS	cell life, antiapoptosis
	protein, post translation, folding
	protein, post translation, targeting

PHYSIOLOGICAL PROCESS

nervous system

text	wound healing

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein

cell & other

REGULATION

induced by

hypoxia,tunicamycin,2-desoxyglucose,oxidized LDL

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in atherosclerotic plaques

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS