Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HSD17B12 contributors: mct/npt - updated : 15-04-2008
HGNC name hydroxysteroid (17-beta) dehydrogenase 12
HGNC id 18646
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four transmembrane domains
  • dilysin ER retention motif
    • HOMOLOGY
    interspecies homolog to Drosophila CG1444
    homolog to C.elegans C56G2.6
    Homologene
    FAMILY
  • short chain dehydrogenase superfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • transforming estrone (E1) into estradiol (E2)
  • having a 3-ketoacylCoA reductase activity
  • may playing a critical roles in the physiological processes, such as fatty acid synthesis, in addition to the steroid metabolism
  • major estrogenic 17beta-HSD responsible for the conversion of E1 to E2 in women, especially in the ovary, the predominant source of estrogens before menopause
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    long chain fatty acid elongation
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS