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FLASH GENE

Symbol

HSD17B12

contributors: mct/npt - updated : 15-04-2008

HGNC name	hydroxysteroid (17-beta) dehydrogenase 12
HGNC id	18646

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Respiratory respiratory tract trachea     highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic platelet

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four transmembrane domains
	dilysin ER retention motif

HOMOLOGY

interspecies	homolog to Drosophila CG1444
	homolog to C.elegans C56G2.6

Homologene

FAMILY

short chain dehydrogenase superfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic,microsome

basic FUNCTION	transforming estrone (E1) into estradiol (E2)
	having a 3-ketoacylCoA reductase activity
	may playing a critical roles in the physiological processes, such as fatty acid synthesis, in addition to the steroid metabolism
	major estrogenic 17beta-HSD responsible for the conversion of E1 to E2 in women, especially in the ovary, the predominant source of estrogens before menopause

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

long chain fatty acid elongation

a component

INTERACTION

DNA

RNA

small molecule	cofactor, nucleotide,
	NADPH

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS