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FLASH GENE
Symbol HRASLS2 contributors: mct - updated : 06-12-2010
HGNC name HRAS-like suppressor 2
HGNC id 17824
Location 11q12.3      Physical location : 63.320.241 - 63.330.855
Synonym name HRAS-like suppressor family 2
Synonym symbol(s) FLJ20556, PLA1/2-2
DNA
TYPE functioning gene
STRUCTURE 10.61 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
POLR2G 11q13.1 polymerase (RNA) II (DNA directed) polypeptide G TAF6L 11q13.1 TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa LOC387617 11 hypothetical gene supported by NM_018336 LOC374395 11q12.3 similar to RIKEN cDNA 1810059G22 NXF1 11q12-q13 nuclear RNA export factor 1 STX5A 11cen-q12.1 syntaxin 5A FLJ10439 11q12.3 hypothetical protein FLJ10439 SLC3A2 11q12-q22 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 CHRM1 11q12-q13 cholinergic receptor, muscarinic 1 SLC22A6 11q13.1-q13.2 solute carrier family 22 (organic anion transporter), member 6 SLC22A8 11q11.7 solute carrier family 22 (organic anion transporter), member 8 LOC390207 11 similar to Tubulin alpha-4 chain (Alpha-tubulin 4) LOC390208 11 similar to ribosomal protein L29 MGC34821 11q12.3 hypothetical protein MGC34821 LOC387601  putative UST1-like organic anion transporter CCND2P 11q13 cyclin D2 pseudogene LOC387775 11 similar to organic anion transporter 6 SLC22A9 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 9 HRLP5 11q13.2 H-rev107-like protein 5 LGALS12 11q13 lectin, galactoside-binding, soluble, 12 (galectin 12) TMSL5 11 thymosin-like 5 RARRES3 11q23 retinoic acid receptor responder (tazarotene induced) 3 HRASLS2 11q13.1 HRAS-like suppressor 2 HRASLS3 11q13.1 HRAS-like suppressor 3 LOC283241 11q13.1 hypothetical protein LOC283241 DKFZP564J0863 11q13.1 DKFZP564J0863 protein RTN3 11q13 reticulon 3 LOC144097 11q13.1 hypothetical protein BC007540 MARK2 11q12-q13 MAP/microtubule affinity-regulating kinase 2 LOC283248 11q13.1 hypothetical protein LOC283248 FLJ13848 11q13.1 hypothetical protein FLJ13848 COX8 11q13.1 cytochrome c oxidase subunit VIII OTUB1 11q13.1 OTU domain, ubiquitin aldehyde binding 1 LRP16 11q11 LRP16 protein LOC387776 11 LOC387776 FLRT1 11q12-q13 fibronectin leucine rich transmembrane protein 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 785 17.3 162 - 2009 19615464
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly Homo sapiens
Respiratoryrespiratory tracttrachea  highly Homo sapiens
Urinarykidney   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal hydrophobic domain appeared to be indispensable for RAS activities of cancer cells
  • HOMOLOGY
    Homologene
    FAMILY
  • H-rev107 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • suppressed growth and RAS activities of cancer cells
  • with RARRES3 and PLA2G16, are involved in the phospholipid metabolism with different physiological roles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS