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FLASH GENE

Symbol

PROKR2

contributors: mct - updated : 02-10-2024

HGNC name	prokineticin receptor 2
HGNC id	15836

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

KAL3

Susceptibility

to GNRH1 deficiency and failure of reproductive competency to recurrent miscarriage (RM)

Variant & Polymorphism other	PROKR2 L173R is an ancient founder mutation that was not eliminated during evolution despite being associated with GNRH1 deficiency and failure of reproductive competency
	PROKR2 (V331M) variant conferred lower risk for RM and may play protective roles in early pregnancy by altering calcium signaling and facilitating cell invasiveness

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Prokr2-deficient mice display vascular dysmorphology of the fetal testes
	mice lacking Prokr2 have been shown to present abnormal olfactory bulb formation as well as defects in GnRH neuron migration