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FLASH GENE
Symbol PROKR2 contributors: mct - updated : 02-10-2024
HGNC name prokineticin receptor 2
HGNC id 15836
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1157 - 384 - 2002 11886876
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamus predominantly Mus musculus
 brainbasal nuclei   
 braindiencephalonthalamus  
Olfactory (smell)olfactory bulb     Mus musculus
Reproductivefemale systemplacenta  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane helices,
  • three intracellular loops (IL1–3) and the distal region of the of the third intracellular loop of PROKR2 may differentially influence receptor trafficking and G-protein coupling
  • a cytoplasmic C-terminal tail, and C-terminus of PROKR2 is critical for the stability of the ARRB2-receptor complex in the presence of PROK2 ligand
  • mono polymer dimer
    HOMOLOGY
    interspecies homolog to murine Gpr73
    Homologene
    FAMILY G protein coupled receptor family 1
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in the mobilization of calcium
  • stimulation of phosphoinositide turnover
  • activation of p44/p42 MAPK signaling pathways consistent with the effects of prokineticins on smooth muscle contraction and angiogenesis
  • not necessary for suprachiasmatic nucleus cellular timekeeping or entrainment, but it is an essential link for coordination of circadian behavior and physiology by the suprachiasmatic nucleus, especially in defining the onset and maintenance of circadian night
  • mediating circadian control of behavior rather than circadian timing per se
  • having a dimeric structure in neutrophils (pMID: 21161321)
  • PROKR1, but also PROKR2 might mediate a complementary signalling to the RET/GDNF pathway supporting proliferation/survival and differentiation of precursor cells during enteric nervous system (ENS) development
  • undergoes rapid ligand-induced endocytosis, and recycles back to the plasma membrane after the removal of ligand
  • involved in the regulation of sexual maturation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex PROC2/PROCR2 plays a role in GNRH1 neuron development beyond olfactory bulb morphogenesis
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • receptor for prokineticins (PROK2)
  • PROK2-induced the formation of vessel-like structures by aortic endothelial cells expressing only PROKR1, and disorganized the tight junctions in hepatic sinusoidal endothelial cells expressing only PROKR2, confirming the divergent roles of these receptors
  • PROK2 increases the activity of acid-sensing ion channels via the PROKR2 and protein kinase C-dependent signal pathways
  • PKC activation induced PROKR2 endocytosis, however, PKC activation is not necessary for the PROK2-induced PROKR2 endocytosis
  • PROK1 and PROK2 bind to two highly related G protein-coupled receptors (GPCRs), prokineticin receptor 1 (PROKR1) and prokineticin receptor 2 (PROKR2)
  • PROK1, PROK2 increased blood-brain barrier (BBB) permeability, which could be prevented by PROKR1 and PROKR2 antagonists
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) KAL3
    Susceptibility
  • to GNRH1 deficiency and failure of reproductive competency
  • to recurrent miscarriage (RM)
  • Variant & Polymorphism other
  • PROKR2 L173R is an ancient founder mutation that was not eliminated during evolution despite being associated with GNRH1 deficiency and failure of reproductive competency
  • PROKR2 (V331M) variant conferred lower risk for RM and may play protective roles in early pregnancy by altering calcium signaling and facilitating cell invasiveness
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Prokr2-deficient mice display vascular dysmorphology of the fetal testes
  • mice lacking Prokr2 have been shown to present abnormal olfactory bulb formation as well as defects in GnRH neuron migration