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FLASH GENE
Symbol GPHA2 contributors: mlc - updated : 15-12-2007
HGNC name glycoprotein hormone alpha 2
HGNC id 18054
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 23-amino acid signal peptide at its N terminus
  • a potential binding site for the LIM homeodomain transcription factor ISL1
  • 10 cysteine residues likely involved in cystine-knot formation
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY phosphatase 2a regulatory subunit b family.
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • my be directing the localization of the catalytic enzyme to a particular subcellular compartment
  • may serve as a scaffold for the beta-subunit to activate downstream G protein-mediated signaling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component two unique subunits, A2 and B5 (heterodimerize to form a novel thyrotrophic hormone, thyrostimulin)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by ISL1 (this protein associates with endocrine systems including the pituitary and pancreas)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS