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FLASH GENE
Symbol GLYAT contributors: mct/npt - updated : 29-09-2015
HGNC name glycine-N-acyltransferase
HGNC id 13734
Location 11q12.1      Physical location : 58.476.230 - 58.499.447
Synonym name
  • aralkyl-CoA N-acyltransferase
  • acyl-CoA:glycine N-acyltransferase
  • Synonym symbol(s) GAT, ACGNAT, CAT, CLP, HRP-1
    EC.number 2.3.1.13
    DNA
    TYPE functioning gene
    STRUCTURE 23.22 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC219953 11q12.1 similar to seven transmembrane helix receptor LOC219954 11q12.1 similar to Olfactory receptor 9I1 OR9I2P 11q13.1 olfactory receptor, family 9, subfamily I, member 2 pseudogene LOC219956 11q12.1 similar to Olfactory receptor 9Q1 LOC219957 11q12.1 similar to seven transmembrane helix receptor LOC219958 11q12.1 similar to Olfactory receptor 1S2 LOC219959 11q12.1 similar to Olfactory receptor 1S1 LOC219960 11q12.1 similar to Olfactory receptor 10Q1 LOC387772 11 similar to seven transmembrane helix receptor LOC219964 11q12.1 similar to Olfactory receptor 10Q1 LOC390185 11 similar to Olfactory receptor 5B13 LOC390186 11 similar to Olfactory receptor 5B2 (OST073) LOC219965 11q12.1 similar to Olfactory receptor 5B17 LOC390187 11 similar to Olfactory receptor 5B13 LOC390188 11 similar to Olfactory receptor 5B17 LOC390189 11 similar to Olfactory receptor 5B13 LOC390190 11 similar to Olfactory receptor 5B2 (OST073) LOC390191 11 similar to Olfactory receptor 5B16 LOC219968 11q12.1 similar to olfactory receptor MOR202-4 LPXN 11cen-q12.3 leupaxin ZFP91-CNTF 11q12.2 zinc finger protein 91 homolog (mouse), ciliary neurotrophic factor transcription unit ZFP91 11q12 zinc finger protein 91 homolog (mouse) CNTF 11q12.2 ciliary neurotrophic factor GLYAT 11q12.3 glycine-N-acyltransferase BXMAS2-10 11q12.2 BXMAS2-10 MGC15937 11q12.2 similar to RIKEN cDNA 0610008P16 gene LOC387773 11 similar to MGC15937 protein CANP 11q12.2 cancer-associated nucleoprotein FLJ22794 11q12.2 FLJ22794 protein KIAA0937 11q12.3 FLJ22794 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2068 33.9 296 liver 1997 9202629
    5 - 1157 18 163 - 1997 9202629
  • shorter form, distinct C terminus
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • glycine N-acyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • glycine-N-acyltransferase protein conjugating glycine with acyl-CoA substrates in the mitochondria
  • having substantial capacity towards its preferred substrates, with indisputable therapeutic impact
  • is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA and in regulating glucose metabolism and energy metabolism
  • essential to glucose metabolism and energy metabolism, suggesting the gene dual role in both bone development and muscle growth
  • importance of GLYAT gene in co-regulation of bone phenotypes and body lean mass
  • essential to glucose metabolism and energy metabolism, suggesting the gene dual role in both bone development and muscle growth
  • is a phase II metabolic detoxification enzyme for exogenous (xenobiotic) and endogenous carboxylic acids
  • catalyzes the formation of hippurate (N-benzoylglycine) from the corresponding glycine and benzoyl-CoA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS detoxification
    text detoxification of endogenous and xenobiotic acyl-CoA's.
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    is associated to hyperglycemia diseases
    Susceptibility to variation of bone size and body lean mass
    Variant & Polymorphism SNP
  • three SNPs were also associated with variation of bone size and body lean mass
  • SNP variations in GLYAT gene influence the kinetic properties of the enzyme, and may explain some of the inter-individual variation in glycine conjugation capacity, which is relevant to the metabolism of xenobiotics such as aspirin and the industrial solvent xylene
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS