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| male mice Knockout for Gba2 exhibited impaired fertility which is due to globozoospermia, abnormal sperm acrosomes, and defective sperm mobility  | |
GBA2-targeted RNA interference reduces endogenous non-lysosomal glucosylceramidase activity in cells |
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in mice pharmacological inhibition of GBA2 activity is associated with impaired spermatogenesis |
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knock down of mouse Gba2 by antisense morpholino oligonucleotide induced a curly tail phenotype in 12.5% of morphants and a substantial proportion of morphants showed significant motility defects characterized by slower movements and shorter touch-induced escape distances |
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in zebrafish model, human GBA2 mRNA can partially compensate for the loss of endogenous zebrafish mRNA which decreases motility defects |