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FLASH GENE
Symbol GAB3 contributors: - updated : 06-01-2006
HGNC name GRB2-associated binding protein 3
HGNC id 17515
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
 thymus    
Nervousbrain   lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunedendritic cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one PH domain
  • potential SH2 and SH3 domains
    • HOMOLOGY
    interspecies ortholog to murine Gab3
    Homologene
    FAMILY DOS/Gab family member
    CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION unknown
    CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text macrophage differentiation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    loss of Gab3 does not result in detectable defects in normal mouse development, hematopoiesis, or immune system function