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FLASH GENE
Symbol FTSJ1 contributors: mct - updated : 16-10-2017
HGNC name FtsJ homolog 1 (E. coli)
HGNC id 13254
Corresponding disease
MRX44 mental retardation, 44
Location Xp11.23      Physical location : 48.334.548 - 48.344.752
Synonym name
  • S-adenosylmethionine-binding protein
  • rRNA (uridine-2'-O-)-methyltransferase
  • Synonym symbol(s) JM23, SPB1, CDLIV, TRM7, MRX44, MRX9
    EC.number 2.1.1.105
    DNA
    TYPE functioning gene
    STRUCTURE 10.34 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 splicing 2091 36 329 - 2000 10648622
    FTSJ1 Ia
    14 splicing 2191 - 327 - 2000 10648622
  • FTSJ1 Ia
  • an alternate in-frame splice site in the coding region,
  • 9 - 1667 - 192 - 2000 10648622
  • FTSJ1 Ic
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     stomach   highly
    Lymphoid/Immunespleen   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Ftsj1
    homolog to yeast Trm7
    Homologene
    FAMILY
  • methyltransferase superfamily
  • RRMJ family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • may be involved in the processing and modification of rRNA
  • may be playing a role in the regulation of translation
  • widespread conservation of the circuitry for FTSJ1-dependent anticodon loop modification of eukaryotic tRNA(Phe)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX9 , MRX44
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS