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FLASH GENE
Symbol FIBP contributors: mct - updated : 03-01-2019
HGNC name fibroblast growth factor (acidic) intracellular binding protein
HGNC id 3705
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
intracellular,nuclear envelope
basic FUNCTION
  • involved in the mitogenic action of acidic FGF
  • CDK5 and FIBP have a proven essential role in cell division
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CDK5, KIAA0528, FIBP form a stable complex, involved in cell growth and migration, C2CD5 and FIBP being required for the assembly and stability of the complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ORDMR
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlated with chemoresistance and poor prognosis in colorectal cancer (CRC) patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    potential of FIBP as a novel therapeutic target for treating chemoresistant CRC through inhibition of GSK3B-related signaling
    ANIMAL & CELL MODELS