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FLASH GENE
Symbol FIBP contributors: mct - updated : 03-01-2019
HGNC name fibroblast growth factor (acidic) intracellular binding protein
HGNC id 3705
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
intracellular,nuclear envelope
basic FUNCTION
  • involved in the mitogenic action of acidic FGF
  • CDK5 and FIBP have a proven essential role in cell division
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CDK5, KIAA0528, FIBP form a stable complex, involved in cell growth and migration, C2CD5 and FIBP being required for the assembly and stability of the complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ORDMR
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlated with chemoresistance and poor prognosis in colorectal cancer (CRC) patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    potential of FIBP as a novel therapeutic target for treating chemoresistant CRC through inhibition of GSK3B-related signaling
    ANIMAL & CELL MODELS