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FLASH GENE
Symbol FBXL8 contributors: - updated : 30-07-2004
HGNC name F-box and leucine-rich repeat protein 8
HGNC id 17875
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a 40AAs F box motif and several leucine rich repeats (LRR) motifs at the C terminus
HOMOLOGY
Homologene
FAMILY F box protein family
CATEGORY adaptor
SUBCELLULAR LOCALIZATION     intracellular
basic FUNCTION
  • phosphorylation dependent ubiquination
  • substrate recognition subunit of SCF ubiquitin protein ligase complex
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component one of the four subunits of the E3 ubiquitin protein ligase complex (SCF) with SKP1,CUL1,RBX1,F boxprotein bringing ubiquitin conjugating enzymes to substrates recruited by F-box
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS