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FLASH GENE
Symbol EPHA5 contributors: mct/npt - updated : 08-02-2012
HGNC name EPH receptor A5
HGNC id 3389
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SAM domain
  • two fibronectin type 3 domain
    • HOMOLOGY
    interspecies homolog to murine Epha5
    Homologene
    FAMILY
  • TYR family of protein kinases
  • ephrin receptor subfamily
    • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • may be involved in the maintenance of the adult nervous system and contributing to glioma development
  • key player in controlling these cell movements in many tissues and at multiple stages of patterning
  • EFNA5-EPHA4/EPHA5 system plays an important role in the direct pathway-dependent regulation of the substantia nigra pars reticulata in both acute and adaptive cocaine responses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    EFNA5 and EPHA5 signals play a necessary, activity-independent role in the initiation of the early phases of synaptogenesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TIAM1 plays a role in clathrin-dependent endocytosis of EPHA8-EPHA5 complexes
  • EFNA5 interaction with the EPHA5 receptor following neuron-neuron contact during early development of hippocampus induces a complex program of synaptogenic events
  • DLX5 and MSX2 play potentially a critical role in controlling cranial neural tube morphogenesis by regulating cell adhesion via the EPHA5 and EPHA7 pathway
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter methylation in colorectal cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS