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FLASH GENE

Symbol

EPHA5

contributors: mct/npt - updated : 08-02-2012

HGNC name	EPH receptor A5
HGNC id	3389

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q13.1      Physical location : 66.185.281 - 66.535.653
Synonym name	TYRO4 protein tyrosine kinase
	receptor protein-tyrosine kinase HEK7
	ephrin type-A receptor 5 precursor
	tyrosine-protein kinase receptor EHK-1
Synonym symbol(s)	HEK7, CEK7, EHK1, TYRO4
EC.number	2.7.10.1

DNA

TYPE	functioning gene
STRUCTURE	345.86 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 18 - 3349 115 1037 - Wilkinson (2001) variant 2 17 - 3283 - 1015 - Wilkinson (2001)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous nerve spinal nerve sciatic

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Nervous peripherous

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one SAM domain
	two fibronectin type 3 domain

HOMOLOGY

interspecies

homolog to murine Epha5

Homologene

FAMILY	TYR family of protein kinases
	ephrin receptor subfamily

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	may be involved in the maintenance of the adult nervous system and contributing to glioma development
	key player in controlling these cell movements in many tissues and at multiple stages of patterning
	EFNA5-EPHA4/EPHA5 system plays an important role in the direct pathway-dependent regulation of the substantia nigra pars reticulata in both acute and adaptive cocaine responses

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

EFNA5 and EPHA5 signals play a necessary, activity-independent role in the initiation of the early phases of synaptogenesis

a component

INTERACTION

DNA

RNA

small molecule

protein	TIAM1 plays a role in clathrin-dependent endocytosis of EPHA8-EPHA5 complexes
	EFNA5 interaction with the EPHA5 receptor following neuron-neuron contact during early development of hippocampus induces a complex program of synaptogenic events
	DLX5 and MSX2 play potentially a critical role in controlling cranial neural tube morphogenesis by regulating cell adhesion via the EPHA5 and EPHA7 pathway

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by promoter methylation in colorectal cancer patients

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS