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FLASH GENE
Symbol EPHA4 contributors: mct/pgu - updated : 08-02-2016
HGNC name EPH receptor A4
HGNC id 3388
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one SAM motif
  • two fibronectin type 3 domain
    • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • tyr protein kinase family
  • ephrin receptor subfamily
    • CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be playing a role in a signal transduction process involved in hindbrain pattern formation
  • playing a role in local neuronal circuits that control walking
  • involved in neurite outgrowth, early neuronal cell development, neuropeptide signaling/synthesis and neuronal receptor
  • EFNA5-EPHA4/EPHA5 system plays an important role in the direct pathway-dependent regulation of the substantia nigra pars reticulata in both acute and adaptive cocaine responses
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • EPHA4/EFNAA3 signaling is potentially a critical mechanism for astrocytes to regulate synaptic function and plasticity
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between neuronal EPHA4 and glial EFNA3 bidirectionally controls synapse morphology and glial glutamate transport, ultimately regulating hippocampal function
  • mediates at least in part the repulsive effect of EFNA3 in the neurons from the medial ganglionic eminence
  • POU3F4 binds to and directly regulates expression of EPHA4 (
  • direct interaction between SIPA1L3 and EPHA4, building a functional platform for proper ocular development
  • novel role for SORL1 as a physiological and pathological EPHA4 modulator, which attenuates synaptotoxic EPHA4 activation and cognitive impairment associated with APP-induced neurodegeneration in Alzheimer disease
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in Alzheimer disease brains
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS