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FLASH GENE

Symbol

EPHA4

contributors: mct/pgu - updated : 08-02-2016

HGNC name	EPH receptor A4
HGNC id	3388

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q36.1      Physical location : 222.282.748 - 222.437.010
Synonym name	ephrin type-A receptor 4 precursor
	receptor protein-tyrosine kinase HEK8
	tyrosine-protein kinase receptor SEK
Synonym symbol(s)	HEK8, TYRO1, EPA4, SEK
EC.number	2.7.10.1

DNA

TYPE	functioning gene
STRUCTURE	154.26 kb     18 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004438 18 - 6364 NP_004429 110 986 - 2004 12649481

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial         Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	expressed in the developing striatum, an area that is strictly avoided by migrating cortical interneurons

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one SAM motif
	two fibronectin type 3 domain

HOMOLOGY

Homologene

FAMILY	protein kinase superfamily
	tyr protein kinase family
	ephrin receptor subfamily

CATEGORY

enzyme , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may be playing a role in a signal transduction process involved in hindbrain pattern formation
	playing a role in local neuronal circuits that control walking
	involved in neurite outgrowth, early neuronal cell development, neuropeptide signaling/synthesis and neuronal receptor
	EFNA5-EPHA4/EPHA5 system plays an important role in the direct pathway-dependent regulation of the substantia nigra pars reticulata in both acute and adaptive cocaine responses

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

EPHA4/EFNAA3 signaling is potentially a critical mechanism for astrocytes to regulate synaptic function and plasticity

a component

INTERACTION

DNA

RNA

small molecule

protein	interaction between neuronal EPHA4 and glial EFNA3 bidirectionally controls synapse morphology and glial glutamate transport, ultimately regulating hippocampal function
	mediates at least in part the repulsive effect of EFNA3 in the neurons from the medial ganglionic eminence
	POU3F4 binds to and directly regulates expression of EPHA4 (
	direct interaction between SIPA1L3 and EPHA4, building a functional platform for proper ocular development
	novel role for SORL1 as a physiological and pathological EPHA4 modulator, which attenuates synaptotoxic EPHA4 activation and cognitive impairment associated with APP-induced neurodegeneration in Alzheimer disease

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in Alzheimer disease brains

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS