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FLASH GENE
Symbol ELOVL3 contributors: mct - updated : 13-04-2018
HGNC name elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
HGNC id 18047
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1455 - 270 - 2004 14581464
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver     Mus musculus
Skin/Tegumentskin   highly
 skin appendagesskin glandsebaceous gland  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadiposebrown   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumenthair follicle cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N terminal transmembrane segments in the central hydrophilic region
  • a C terminal region with three transmmembrane segments (TM3),
  • a single HXXHH motif
  • a strong signal (dilysine motifs)
    • HOMOLOGY
    Homologene
    FAMILY
  • GNS1/SUR4 family
  • ELOVL gene family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in the biosynthesis of very long chain fatty acids and in the pathogenesis of macular degeneration
  • participating in the formation of specific neutral lipids that are necessary for the function of the skin
  • important regulator of endogenous synthesis of saturated very long chain fatty acids and triglyceride formation in brown adipose tissue during the early phase of the tissue recruitment
  • role for the enzyme is to control the elongation of saturated and monounsaturated fatty acids up to 24 carbons in length
  • C20-C22 saturated and monounsaturated VLCFAs produced by ELOVL3 are indispensable for appropriate synthesis of liver triglycerides, fatty acid uptake, and storage in adipose tissue
  • is involved in elongating saturated and monounsaturated fatty acids, and is a critical enzyme for lipid accumulation in brown adipocytes during the early phase of tissue recruitment
  • is related to increased fatty acid oxidation in brown adipocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LDB1 occupies a regulatory domain of ELOVL3, a gene crucial to normal Brown adipose tissue (BAT) function
    • cell & other
    REGULATION
    Other its expression is transcriptionally controlled and significantly induced by the exposure of the synthetic glucocorticoid dexamethasone
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS