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FLASH GENE

Symbol

KCNJ8

contributors: - updated : 24-05-2006

HGNC name	potassium inwardly-rectifying channel, subfamily J, member 8
HGNC id	6269

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Lymphoid/Immune spleen         Nervous brain diencephalon hypothalamus     Reproductive female system placenta         male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Nervous astrocyte Nervous glia

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two membrane-spanning domains and an amphipatic region pore,including the P domain with the K+ channel signature
	an ATP-binding regulatory domain

mono polymer

homomer , tetramer

HOMOLOGY

Homologene

FAMILY

potassium channel subfamily J

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in the regulation of membrane potential
	potassium non voltage-gated channel, inwardly rectifying

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

constituent with SUR2 of an ATP dependent potassium channel

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS