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FLASH GENE
Symbol EDF1 contributors: mct - updated : 21-08-2013
HGNC name endothelial differentiation-related factor 1
HGNC id 3164
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal region binding to the activators
  • a MBF1 C terminal domain for binding to TBP
    • HOMOLOGY
    interspecies homolog to murine Edf1 (98.6pc)
    homolog to chicken EDF1 (93.2pc)
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery
  • transcriptional coactivator for transcription factors such as FTZ-F1,GCN4,SF1 (NR5A1)
  • recruiting TATA box binding proteins to promoters interactivators an bound
  • enhancing the DNA-binding activity of ATF1, ATF2, CREB1
  • regulating nitric oxid synthase activity by sequestering calmodulin in the cytoplasm
  • required for PPARG-stimulated adipogenesis
  • functions as a coactivator of several transcription factors
  • implicated in molecular events that are pivotal to endothelial function and, therefore, to vascular integrity
  • calmodulin binding protein that regulates calmodulin-dependent enzymes
  • inactivates the calmodulin/calcineurin/NFAT pathway via sequestration of calmodulin, during early adipogenesis
  • might have a complex role during adipose differentiation
    • CELLULAR PROCESS cell life, differentiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text
  • repression of endothelial cells differentiation
  • angiogenesis
    • PATHWAY
    metabolism lipid/lipoprotein
    signaling
    EDF1/CALM1/PPP3CA/NFATC1 pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TBP, TFIID complex, NR5A2, NR1H3 and PPARG
  • binding NR5A1, ATF1, FOS and JUN
  • in endothelial cells, bound with CALM1, through its IQ domain sequestering this complex in the cytoplasm of endothelial cells
  • is a cofactor of PPARG
  • associates with calmodulin and calcineurin, most likely inactivating calcineurin
  • can associate in a protein complex with CALM1, and PPP3CA but not with NFATC1, suggesting that EDF1 is a key element in the CALM1/PPP3CA/NFATC1 pathway
    • cell & other
    REGULATION
    Other phosphorylated by PKA and PKC
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS