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FLASH GENE
Symbol EDARADD contributors: mct - updated : 31-08-2016
HGNC name EDAR-associated death domain
HGNC id 14341
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal region comprising the TRAF interaction consensus sequence
  • a C terminal DEATH domain
    • HOMOLOGY
    interspecies homolog to murine Edaradd
    Homologene
    FAMILY enolase family
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text coexpressed with EDAR
    basic FUNCTION
  • interacting with EDAR death domain, coupling the receptor to EDA signaling pathway during morphogenesis of ectodermal organs and mediating activation of NFKB, possibly by recruiting TRAF2 to the receptor-signaling complex
  • playing a role as a downstream effector in EDAR signaling
    • CELLULAR PROCESS cell life, differentiation
    cell life, cell death/apoptosis
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text skin and appendages
    PATHWAY
    metabolism
    signaling signal transduction
    signaling pathway towards NF-kappa B
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TRAF1, TRAF2, TRAF3
  • interacting with EDAR
  • essential role of interaction between EDAR and EDARADD in ectodermal development
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HEDAD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    murine crinkled (Cr) phenotypically identical to Tabby and downless