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FLASH GENE
Symbol EBF2 contributors: mct/npt - updated : 03-03-2017
HGNC name early B-cell factor 2
HGNC id 19090
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • Olf/EBF family of helix-loop-helix transcription factors
  • COE family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • olfactory gene regulator
  • recognizes variations of the palindromic sequence
    • 5'-ATTCCCNNGGGAATT-3'
  • keystone in the regulatory network that coordinates B cell lineage specification and commitment (Lukin 2008)
  • both EBF2 and EBF3, singly or together, control the migration of Cajal-Retzius (CR) cells arising in the cortical hem, and Ebfs directly regulate CR cell development
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text olfactory neurodevelopment
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • FOXG1 binds to mammalian-specific noncoding sequences to repress over 12 transcription factors expressed in early progenitors, including EBF2/3, DMRT3, DMRTA1, and EYA2
  • DPF3 is a direct transcriptional target of EBF2 in brown adipocytes, thereby establishing a regulatory module through which EBF2 activates and also recruits DPF3-anchored BAF complexes to chromatin
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS