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FLASH GENE

Symbol

EBF2

contributors: mct/npt - updated : 03-03-2017

HGNC name	early B-cell factor 2
HGNC id	19090

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022659 16 - 2297 NP_073150 - 575 - Nusbaum (2006)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive stomach         Respiratory respiratory tract trachea         respiratory tract larynx

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic mature hematopoietic Lymphoid/Immune B cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY	Olf/EBF family of helix-loop-helix transcription factors
	COE family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	olfactory gene regulator
	recognizes variations of the palindromic sequence
	5'-ATTCCCNNGGGAATT-3'
	keystone in the regulatory network that coordinates B cell lineage specification and commitment (Lukin 2008)
	both EBF2 and EBF3, singly or together, control the migration of Cajal-Retzius (CR) cells arising in the cortical hem, and Ebfs directly regulate CR cell development

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

development

text	olfactory neurodevelopment

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein	FOXG1 binds to mammalian-specific noncoding sequences to repress over 12 transcription factors expressed in early progenitors, including EBF2/3, DMRT3, DMRTA1, and EYA2
	DPF3 is a direct transcriptional target of EBF2 in brown adipocytes, thereby establishing a regulatory module through which EBF2 activates and also recruits DPF3-anchored BAF complexes to chromatin

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS