Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DPYSL4 contributors: mct/npt - updated : 08-06-2010
HGNC name dihydropyrimidinase-like 4
HGNC id 3016
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an amidohydrolase motif
    • HOMOLOGY
    interspecies ortholog to murine Dpysl4
    ortholog to rattus dpysl4
    Homologene
    FAMILY
  • dehydropyrimidinase family
    • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text N-terminal truncated DPYSL4 underwent nuclear translocation through nuclear pores (Aylsworth 2009)
    basic FUNCTION
  • may be involved in the axonal growth during development by transducing signals from different semaphorins
  • having an important role in dendrite arborization, guide-posts navigation, and neuronal plasticity (Quach 2008)
  • key modulator of cytoskeletons during neurite outgrowth in response to chemorepulsive guidance molecules (Aylsworth 2009)
  • role in attenuating neurite outgrowth possibility through inhibiting microtubule polymerization, and also revealed its novel association with vimentin during nuclear condensation prior to neuronal death (Aylsworth 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • form a large complex composed of DPYSL5 and other unidentified proteins (Inatome 2000)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DPYSL5 (Inatome 2000)
  • CRHR2 activation decrease DPYSL4 expression in hippocampal neurons via a mechanism that is dependent on PLC/PKC signaling pathways
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Down syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS