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FLASH GENE
Symbol DPYSL4 contributors: mct/npt - updated : 08-06-2010
HGNC name dihydropyrimidinase-like 4
HGNC id 3016
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampus highly
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text expressed mostly in the nervous system during development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an amidohydrolase motif
    • HOMOLOGY
    interspecies ortholog to murine Dpysl4
    ortholog to rattus dpysl4
    Homologene
    FAMILY
  • dehydropyrimidinase family
    • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text N-terminal truncated DPYSL4 underwent nuclear translocation through nuclear pores (Aylsworth 2009)
    basic FUNCTION
  • may be involved in the axonal growth during development by transducing signals from different semaphorins
  • having an important role in dendrite arborization, guide-posts navigation, and neuronal plasticity (Quach 2008)
  • key modulator of cytoskeletons during neurite outgrowth in response to chemorepulsive guidance molecules (Aylsworth 2009)
  • role in attenuating neurite outgrowth possibility through inhibiting microtubule polymerization, and also revealed its novel association with vimentin during nuclear condensation prior to neuronal death (Aylsworth 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • form a large complex composed of DPYSL5 and other unidentified proteins (Inatome 2000)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DPYSL5 (Inatome 2000)
  • CRHR2 activation decrease DPYSL4 expression in hippocampal neurons via a mechanism that is dependent on PLC/PKC signaling pathways
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Down syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS