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FLASH GENE

Symbol

DPYSL4

contributors: mct/npt - updated : 08-06-2010

HGNC name	dihydropyrimidinase-like 4
HGNC id	3016

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006426 14 - 2732 NP_006417 - 572 - Hamajima (1996)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus   highly Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	expressed mostly in the nervous system during development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an amidohydrolase motif

HOMOLOGY

interspecies	ortholog to murine Dpysl4
	ortholog to rattus dpysl4

Homologene

FAMILY

dehydropyrimidinase family

CATEGORY

enzyme , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	N-terminal truncated DPYSL4 underwent nuclear translocation through nuclear pores (Aylsworth 2009)

basic FUNCTION	may be involved in the axonal growth during development by transducing signals from different semaphorins
	having an important role in dendrite arborization, guide-posts navigation, and neuronal plasticity (Quach 2008)
	key modulator of cytoskeletons during neurite outgrowth in response to chemorepulsive guidance molecules (Aylsworth 2009)
	role in attenuating neurite outgrowth possibility through inhibiting microtubule polymerization, and also revealed its novel association with vimentin during nuclear condensation prior to neuronal death (Aylsworth 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

form a large complex composed of DPYSL5 and other unidentified proteins (Inatome 2000)

INTERACTION

DNA

RNA

small molecule

protein	interacting with DPYSL5 (Inatome 2000)
	CRHR2 activation decrease DPYSL4 expression in hippocampal neurons via a mechanism that is dependent on PLC/PKC signaling pathways

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in Down syndrome

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS