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FLASH GENE
Symbol DPYSL3 contributors: mct - updated : 27-09-2018
HGNC name dihydropyrimidinase-like 3
HGNC id 3015
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
an amidohydrolase motif
conjugated PhosphoP
HOMOLOGY
interspecies ortholog to murine Dpysl3
homolog to rattus dpysl3
Homologene
FAMILY
  • dehydropyrimidinase family
  • collapsin response mediator protein (CRMP) family
    • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • dihydropyrimidase activity
  • may regulate vesicle function in the growth cone
  • DPYSL3 and GAP43 are both involved in neurite outgrowth, a crucial process for the differentiation of neurons
  • regulates the inflammatory response of activated microglia
  • dual role for DPYSL3 in regulating the actin and microtubule growth cone cytoskeleton
  • DPYSL2 and DPYSL3 interacted with one another coordinately to promote growth cone development and axonal elongation
  • DPYSL2 and DPYSL3 form likely complexes to bridge microtubules and actin and thus work cooperatively to regulate growth cone development and axonal elongation
  • CRMP1 and DPYSL3 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex
  • is a novel negative regulator of osteoblast differentiation
  • is a protein exhibiting sex-different expression during sexual differentiation of the hypothalamic sexually dimorphic nucleus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a key physiological substrate of GSK3B in regulating chromosomal alignment and mitotic progression through its effect on spindle microtubule
  • increased DPYSL3 expression mediated by the activation of VEGFA signaling facilitates gastric tumor growth and metastasis, which may have clinical implications associated with a reduced survival rate in gastric cancer patients
  • CAPN2 may contribute to the promoter methylation of DPYSL3 to repress its transcription, leading to the metastasis of Prostate carcinoma via enhancing VEGFC expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Down syndrome
    Susceptibility
  • to Autism spectrum disorders (ASD)
  • to amyotrophic lateral sclerosis (ALS)
    • Variant & Polymorphism SNP , other
  • variant (S541Y) of DPYSL3 in a male ASD patient, mutation resulting in altered DPYSL3 function in neurons, more severe in the male, indicating a functional link between a case-specific, rare variant of DPYSL3, and several characteristics of ASD, including sexual differences
  • association between the rs147541241 variant and ALS; this variant variant appears to shorten motor neuron survival through a detrimental effect on axonal growth
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Crmp4-deficient mice (Crmp4-/- ) displayed a 40p100 increase in bone mass, increased mineral apposition rate, and bone formation rate, compared to wild-type controls