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FLASH GENE

Symbol

DPYSL3

contributors: mct - updated : 27-09-2018

HGNC name	dihydropyrimidinase-like 3
HGNC id	3015

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001197294 14 - 5496 NP_001184223 - 684 - 2016 2747532 CRMP4b CRMP4a and CRMP4b exhibit opposing functions in neurite outgrowth CRMP4b expression was higher in gastric cancer cell lines than in the normal gastric epithelial cell CRMP4a and CRMP4b have opposite effects on cell proliferation, migration, and invasion in gastric cancer NM_001387 14 - 5066 NP_001378 - 570 - 2016 2747532 CRMP4a CRMP4a and CRMP4b exhibit opposing functions in neurite outgrowth CRMP4a and CRMP4b have opposite effects on cell proliferation, migration, and invasion in gastric cancer.

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain         Homo sapiens Fetal Respiratory lung         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Muscular myoblast

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an amidohydrolase motif

conjugated

PhosphoP

HOMOLOGY

interspecies	ortholog to murine Dpysl3
	homolog to rattus dpysl3

Homologene

FAMILY	dehydropyrimidinase family
	collapsin response mediator protein (CRMP) family

CATEGORY

enzyme , signaling

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	dihydropyrimidase activity
	may regulate vesicle function in the growth cone
	DPYSL3 and GAP43 are both involved in neurite outgrowth, a crucial process for the differentiation of neurons
	regulates the inflammatory response of activated microglia
	dual role for DPYSL3 in regulating the actin and microtubule growth cone cytoskeleton
	DPYSL2 and DPYSL3 interacted with one another coordinately to promote growth cone development and axonal elongation
	DPYSL2 and DPYSL3 form likely complexes to bridge microtubules and actin and thus work cooperatively to regulate growth cone development and axonal elongation
	CRMP1 and DPYSL3 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex
	is a novel negative regulator of osteoblast differentiation
	is a protein exhibiting sex-different expression during sexual differentiation of the hypothalamic sexually dimorphic nucleus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	is a key physiological substrate of GSK3B in regulating chromosomal alignment and mitotic progression through its effect on spindle microtubule
	increased DPYSL3 expression mediated by the activation of VEGFA signaling facilitates gastric tumor growth and metastasis, which may have clinical implications associated with a reduced survival rate in gastric cancer patients
	CAPN2 may contribute to the promoter methylation of DPYSL3 to repress its transcription, leading to the metastasis of Prostate carcinoma via enhancing VEGFC expression

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in Down syndrome

Susceptibility

to Autism spectrum disorders (ASD) to amyotrophic lateral sclerosis (ALS)

Variant & Polymorphism SNP , other	variant (S541Y) of DPYSL3 in a male ASD patient, mutation resulting in altered DPYSL3 function in neurons, more severe in the male, indicating a functional link between a case-specific, rare variant of DPYSL3, and several characteristics of ASD, including sexual differences
	association between the rs147541241 variant and ALS; this variant variant appears to shorten motor neuron survival through a detrimental effect on axonal growth

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Crmp4-deficient mice (Crmp4-/- ) displayed a 40p100 increase in bone mass, increased mineral apposition rate, and bone formation rate, compared to wild-type controls