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FLASH GENE
Symbol DPYSL3 contributors: mct - updated : 27-09-2018
HGNC name dihydropyrimidinase-like 3
HGNC id 3015
DNA
TYPE functioning gene
STRUCTURE 119.25 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure a myoD/myogenin site downstream the promoter
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 5496 - 684 - 2016 2747532
  • CRMP4b
  • CRMP4a and CRMP4b exhibit opposing functions in neurite outgrowth
  • CRMP4b expression was higher in gastric cancer cell lines than in the normal gastric epithelial cell
  • CRMP4a and CRMP4b have opposite effects on cell proliferation, migration, and invasion in gastric cancer
    • 14 - 5066 - 570 - 2016 2747532
  • CRMP4a
  • CRMP4a and CRMP4b exhibit opposing functions in neurite outgrowth
  • CRMP4a and CRMP4b have opposite effects on cell proliferation, migration, and invasion in gastric cancer.
    		•
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain     Homo sapiensFetal
    Respiratorylung    
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		an amidohydrolase motif
    conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine Dpysl3
    homolog to rattus dpysl3
    Homologene
    FAMILY
  • dehydropyrimidinase family
  • collapsin response mediator protein (CRMP) family
    • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • dihydropyrimidase activity
  • may regulate vesicle function in the growth cone
  • DPYSL3 and GAP43 are both involved in neurite outgrowth, a crucial process for the differentiation of neurons
  • regulates the inflammatory response of activated microglia
  • dual role for DPYSL3 in regulating the actin and microtubule growth cone cytoskeleton
  • DPYSL2 and DPYSL3 interacted with one another coordinately to promote growth cone development and axonal elongation
  • DPYSL2 and DPYSL3 form likely complexes to bridge microtubules and actin and thus work cooperatively to regulate growth cone development and axonal elongation
  • CRMP1 and DPYSL3 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex
  • is a novel negative regulator of osteoblast differentiation
  • is a protein exhibiting sex-different expression during sexual differentiation of the hypothalamic sexually dimorphic nucleus
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a key physiological substrate of GSK3B in regulating chromosomal alignment and mitotic progression through its effect on spindle microtubule
  • increased DPYSL3 expression mediated by the activation of VEGFA signaling facilitates gastric tumor growth and metastasis, which may have clinical implications associated with a reduced survival rate in gastric cancer patients
  • CAPN2 may contribute to the promoter methylation of DPYSL3 to repress its transcription, leading to the metastasis of Prostate carcinoma via enhancing VEGFC expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Down syndrome
    Susceptibility
  • to Autism spectrum disorders (ASD)
  • to amyotrophic lateral sclerosis (ALS)
    • Variant & Polymorphism SNP , other
  • variant (S541Y) of DPYSL3 in a male ASD patient, mutation resulting in altered DPYSL3 function in neurons, more severe in the male, indicating a functional link between a case-specific, rare variant of DPYSL3, and several characteristics of ASD, including sexual differences
  • association between the rs147541241 variant and ALS; this variant variant appears to shorten motor neuron survival through a detrimental effect on axonal growth
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Crmp4-deficient mice (Crmp4-/- ) displayed a 40p100 increase in bone mass, increased mineral apposition rate, and bone formation rate, compared to wild-type controls