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FLASH GENE
Symbol DPM2 contributors: mct - updated : 25-02-2016
HGNC name dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
HGNC id 3006
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • two transmembrane domains
  • a C terminal ER localisation
    • HOMOLOGY
    Homologene
    FAMILY
  • DPM2 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • regulating the biodynthesis of dolichol-phosphate mannose by DPM1 stabilyzing DPM3 which stabilizes DPM1
  • regulating glycosyl phosphatidylinositol biosynthesis (first step)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    N-glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DPM1
  • DPM3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1U
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS