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FLASH GENE
Symbol DPM2 contributors: mct - updated : 25-02-2016
HGNC name dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
HGNC id 3006
Corresponding disease
CDG1U congenital disorder of glycosylation, type Iu
Location 9q34.11      Physical location : 130.697.373 - 130.700.763
Synonym name
  • dolichol phosphate-mannose synthase 2
  • dolichol phosphate-mannose biosynthesis regulatory protein
  • Synonym symbol(s) MGC21559, MGC111193, FLJ80013
    EC.number 2.4.1.83
    DNA
    TYPE functioning gene
    STRUCTURE 3.39 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ZNF79 9q34.1 zinc finger protein 79 (pT7) RPL12 9q34 ribosomal protein L12 LRSAM1 9q34.13 leucine rich repeat and sterile alpha motif containing 1 DKFZP434H0820 9q34.13 hypothetical protein DKFZp434H0820 STXBP1 9q34.1 syntaxin binding protein 1 LOC286207 9q34.13 hypothetical protein LOC286207 LOC138428 9q34.13 hypothetical protein LOC138428 TTC16 9q34.13 tetratricopeptide repeat domain 16 TOR2A 9q34.11 torsin family 2, member A SH2D3C 9q34.13 SH2 domain containing 3C CDK9 9q34.1 cyclin-dependent kinase 9 (CDC2-related kinase) FPGS 9cen-q34.11 folylpolyglutamate synthase ENG 9q34.1 endoglin (Osler-Rendu-Weber syndrome 1) AK1 9q34.12 adenylate kinase 1 ST6GALNAC6 9q34.13 adenylate kinase 1 SIAT7D 9q34.1 sialyltransferase 7D ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) MGC46424 9q34.13 hypothetical protein MGC46424 LOC389790 9 similar to phosphatidylinositol phosphate kinase-like protein DPM2 9q34.13 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit FLJ10232 9q34.13 hypothetical protein FLJ10232 DKFZp762G199 9q34.13 hypothetical protein DKFZp762G199 MCSC 9q34.13 mitochondrial Ca2+-dependent solute carrier PTGES2 9q34.13 prostaglandin E synthase 2 LOC389791 9 hypothetical gene supported by AK094537 LCN2 9q34 lipocalin 2 (oncogene 24p3) C9orf16 9q34.1 chromosome 9 open reading frame 16 CIZ1 9q34.13 chromosome 9 open reading frame 16 DNM1 9q34 dynamin 1 GOLGA2 9q34.13 golgi autoantigen, golgin subfamily a, 2 LOC375757 9q34.13 hypothetical protein LOC375757 FLJ21673 9q34.13 hypothetical protein FLJ21673 CLONE24922
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1561 92 84 - 2005 16280320
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • two transmembrane domains
  • a C terminal ER localisation
  • HOMOLOGY
    Homologene
    FAMILY
  • DPM2 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • regulating the biodynthesis of dolichol-phosphate mannose by DPM1 stabilyzing DPM3 which stabilizes DPM1
  • regulating glycosyl phosphatidylinositol biosynthesis (first step)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    N-glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DPM1
  • DPM3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1U
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS