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FLASH GENE
Symbol DNAJB4 contributors: mct/pgu - updated : 16-03-2011
HGNC name DnaJ (Hsp40) homolog, subfamily B, member 4
HGNC id 14886
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal J domain,(AAs 1-67) that mediates interactions with Hsp70 and regulates ATPase activity of Hsp70
  • a glycine and phenylalanine (G/F)-rich region, (positions 68&
    • 65533;141AA) that is disordered and possibly acts as a flexible linker
  • a non-typical caspase-3 cleavage site (MEID) at AA 125&
    • 65533;128
  • C-terminal domain (positions 200&
    • 65533;321) forming a beta-sheet structure involved in substrate binding and presentation
    HOMOLOGY
    interspecies homolog to Drosophila DnaJ-1
    homolog to C.elegans dnj-13
    Homologene
    FAMILY
  • DNAJ/HSP40 protein family
  • subfamily B
    • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • having a heat shock protein activity
  • tumor and invasion suppressor that inhibits tumorigenesis and cancer metastasis
  • switches the role of NPM1, which can act as tumor suppressor or oncogene, by modulating the oligomerization of NPM1 via HLJ1-NPM1 heterodimer formation and recruiting AP-2alpha to the MMP2 promoter
  • tumor suppressor protein closely related to relapse and survival in non-small cell lung cancer (NSCLC) patients
  • promotes UV-induced apoptosis through enhancing JNK and caspase-3 activation in non-small cell lung cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with the nuclear protein nucleophosmin (NPM1), forming a multiprotein complex that alters the nucleolar distribution and oligomerization state of NPM1
  • substrate of caspase-3 during the UV-induced apoptotic process
  • association between DNAJB4 and beta-actin, increased by acidic stress, to modulate migration of human lung cancer cells
    • cell & other
    REGULATION
    activated by via enhancer AP1 binding to promoter YY1 and the coactivator, EP300, through DNA bending and multiprotein complex formation
    induced by heat shock
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS