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FLASH GENE

Symbol

DNAJB4

contributors: mct/pgu - updated : 16-03-2011

HGNC name	DnaJ (Hsp40) homolog, subfamily B, member 4
HGNC id	14886

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	12.36 kb     3 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007034 3 - 2250 NP_008965 - 337 - 1998 9546042

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver       moderately Endocrine pancreas       moderately Nervous brain       moderately Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal J domain,(AAs 1-67) that mediates interactions with Hsp70 and regulates ATPase activity of Hsp70
	a glycine and phenylalanine (G/F)-rich region, (positions 68&
	65533;141AA) that is disordered and possibly acts as a flexible linker
	a non-typical caspase-3 cleavage site (MEID) at AA 125&
	65533;128
	C-terminal domain (positions 200&
	65533;321) forming a beta-sheet structure involved in substrate binding and presentation

HOMOLOGY

interspecies	homolog to Drosophila DnaJ-1
	homolog to C.elegans dnj-13

Homologene

FAMILY	DNAJ/HSP40 protein family
	subfamily B

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	having a heat shock protein activity
	tumor and invasion suppressor that inhibits tumorigenesis and cancer metastasis
	switches the role of NPM1, which can act as tumor suppressor or oncogene, by modulating the oligomerization of NPM1 via HLJ1-NPM1 heterodimer formation and recruiting AP-2alpha to the MMP2 promoter
	tumor suppressor protein closely related to relapse and survival in non-small cell lung cancer (NSCLC) patients
	promotes UV-induced apoptosis through enhancing JNK and caspase-3 activation in non-small cell lung cancer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	specifically interacts with the nuclear protein nucleophosmin (NPM1), forming a multiprotein complex that alters the nucleolar distribution and oligomerization state of NPM1
	substrate of caspase-3 during the UV-induced apoptotic process
	association between DNAJB4 and beta-actin, increased by acidic stress, to modulate migration of human lung cancer cells

cell & other

REGULATION

activated by

via enhancer AP1 binding to promoter YY1 and the coactivator, EP300, through DNA bending and multiprotein complex formation

induced by

heat shock

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS