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FLASH GENE

Symbol

DLAT

contributors: mct - updated : 23-06-2021

HGNC name	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)
HGNC id	2896

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth       highly Lymphoid/Immune lymph node       highly Nervous brain         Reproductive male system testis     highly Respiratory respiratory tract trachea     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two lipoyl-binding domains
	E3 binding domain
	a catalytic domain

HOMOLOGY

intraspecies

homolog to 2 oxoacid dehydrogenases acetyl-transferase

Homologene

FAMILY

2-oxoacid dehydrogenase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix

basic FUNCTION	conversion of pyruvate to involved in the production of acetyl-CoA and carbone dioxide
	novel function of DLAT in the nucleus, suggesting nuclear-mitochondrial crosstalk through the interaction between STAT5 and DLAT
	radiation-induced blockade of autophagic flux stimulates redirection of intracellular molecules such as PDCE2 to the cell surface via a non-canonical secretory autophagy pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

energetic

signaling

a component	E2 component of pyruvate dehydrogenase complex
	multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

INTERACTION

DNA

RNA

small molecule	metal binding,
	biotin
	lipoate CoA
	binds 2 lipoyl cofactors covalently

protein	binding HLA-A*0201
	STAT5A-mediated repression of mtDNA expression also positively correlated with STAT5A binding to DLAT, both a gate-keeping metabolic enzyme and a component of mtDNA nucleoid in mitochondrial matrix

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DLATD

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in placentas from pregnancies with IUGR constitutional     --over   of DLAT was seen in the damaged small bile ducts (SBDs) in primary biliary cirrhosis (PBC) and the expression was significantly more frequent in PBC than in control livers

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS