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Symbol ZFP36L1 contributors: mct/ - updated : 05-03-2016
HGNC name zinc finger protein 36, C3H type-like 1
HGNC id 1107
Location 14q24.1      Physical location : 69.254.374 - 69.259.785
Synonym name
  • tetradecanoyl phorbol acetate (TPA)-inducible sequence 11b
  • butyrate response factor 1
  • B-cell early response gene encoding a 36-kD protein
  • protein TIS11B
  • Synonym symbol(s) BRF1, TIS11B, ERF1, BERG36, RNF162B, cMG1, Berg36, ERF-1
    TYPE functioning gene
    STRUCTURE 8.59 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    text structure promoter containing motifs seen in other early-response genes
    MAPPING cloned Y linked N status provisional
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3022 - 338 - 2020 31551365
    3 - 3212 - 407 - 2020 31551365
    3 - 3170 - 338 - 2020 31551365
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
     thyroid   highly
    Hearing/Equilibriumear   highly
    Respiratoryrespiratory tracttrachea  highly
    Skin/Tegumentskin     Homo sapiens
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermisstratum basale  Homo sapiens
    cell lineage
    cell lines
    at STAGE
  • transactivation domains
  • a distinguishing putative zinc finger domain with a repeating cys-his motif (two C3H1-type zinc fingers)
  • conjugated MetalloP
    interspecies homolog to murine Zfp36l1
    homolog to C.elegans f38b7.1b
    intraspecies homolog to tristetraprolin
  • CCCH tandem zinc finger proteins (TTP family)
  • TIS11 family of early response genes
  • tristetraprolin family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    text shuttle between the nucleus and cytoplasm
    basic FUNCTION
  • specifying a putative nuclear transcription factor, functioning in regulating the response to growth factors
  • acting as as an essential regulator of ARE-dependent mRNA decay
  • might also be an important player during myogenic differentiation and regeneration, and an important regulator of myogenesis
  • may be an important regulator of VEGF expression
  • modulator of vascular endothelium growth factor (VEGF) mRNA stability, and important role of ZFP36L1 in wound healing
  • role for ZFP36L1 and ZFP36L2 during thymocyte development and in the prevention of malignant transformation
  • negatively regulates erythroid differentiation by directly binding the 3prime untranslated region of STAT5B encoding mRNA
  • effective in repressing a broad spectrum of target mRNAs bearing structurally distinct AREs in tumor cells
  • enhances vascular endothelial growth factor (VEGF) mRNA decay through its interaction with AU-rich elements within VEGF 3prime-untranslated region
  • involved in AU-rich-dependent regulation of mRNA stability/degradation
  • ZFP36L1-mediated mechanism is used by endothelial cells under hypoxia for controlling DLL4 mRNA levels
  • new function in mammalian cell mRNA 3prime-end maturation
  • acts as a positive regulator to participate in monocyte/macrophage differentiation
  • in developing B lymphocytes, the RNA-binding proteins (RBPs) ZFP36L1 and ZFP36L2 are critical for maintaining quiescence before precursor B cell receptor (pre-BCR) expression and for reestablishing quiescence after pre-BCR-induced expansion
  • ZFP36, ZFP36L1, and ZFP36L2, regulates the production of growth factors and cytokines via destabilization of the respective mRNAs
  • both ZFP36 and ZFP36L1 influence keratinocyte cell cycle, differentiation, and apoptosis in a distinct manner
  • in addition to controlling the timing of proliferation at thymic beta-selection, posttranscriptional control by ZFP36L1/L2 limits DNA damage responses, which are known to promote thymocyte differentiation
  • indispensable role for ZFP36L1 as the regulator of a post-transcriptional hub that determined the identity of marginal-zone B cells by promoting their proper localization and survival
  • ZFP36L1 controlled a gene-expression program related to signaling, cell adhesion and locomotion
  • ZFP36L1-dependent regulation of bile acid metabolism is an important metabolic contributor to obesity and hepatosteatosis
  • ZFP36L1 and ZFP36L2 inhibit cell proliferation in a CCND-dependent and TP53-independent manner
  • RNA-binding protein ZFP36L1 functions as a tumor suppressor by regulating the mRNA stability of a number of mRNAs involved in hypoxia and cell-cycle signaling
  • ZFP36L1 and ZFP36L2 act redundantly in myogenesis
  • ZFP36, ZFP36L1, and ZFP36L2, play key roles in the post-transcriptional regulation of gene expression
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    text required for apoptosis in Ramos B cells induced through Ca2+ signaling and as a target for IL-4
    a component
    DNA binding
    small molecule metal binding,
    zinc Zn2+
  • negative regulator of VEGFA gene activity during development
  • interact with AU-rich elements in the 3prime untranslated region of mRNA, which leads to mRNA degradation and translational repression
  • Dll4 is a physiological target of ZFP36L1 (binds to endogenous DLL4 mRNA, and represses mRNA expression without affecting its stability)
  • ZFP36L1 negatively regulates plasmacytoid differentiation, at least in part, by targeting the expression of PRDM1
  • ZFP36L1 interacting with and mediating degradation of BCL2 mRNA as an important target through which ZFP36L1 mediates its pro-apoptotic effects in malignant B-cells
  • is a potent regulator of keratinocyte VEGFA production
  • ZFP36L1 overexpression might repress adipogenesis at least by down-regulating PPARG expression through post-transcriptional mechanisms
  • cell & other
    induced by various agonists such as the phorbol ester.TPA and the polypetide mitogen EGF
    calcium ionophore
    a broad variety of growth factors and cytokines, and by scratch wounding
    corresponding disease(s)
    Variant & Polymorphism
    Candidate gene
    Therapy target
    R9-ZFP36L1 may potentially control invasive behavior of aggressive tumors (R9-ZFP36L1 fusion protein may represent a novel antiangiogenic and antitumoral agent)
    ZFP36L1-mediated regulatory circuit through repressing CDK6 expression during monocyte/macrophage differentiation, which may also provide a therapeutic target for AML therapy