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FLASH GENE
Symbol DGKH contributors: mct/npt - updated : 25-11-2009
HGNC name diacylglycerol kinase, eta
HGNC id 2854
Location 13q14.11      Physical location : 42.622.888 - 42.803.888
Synonym name
  • DAG kinase eta
  • diglyceride kinase eta
  • Synonym symbol(s) DGKETA, DKFZp761I1510
    EC.number 2.7.1.107
    DNA
    TYPE functioning gene
    STRUCTURE 181.00 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 4117 128 1164 ubiquitous Murakami (2003)
  • also known as DGK eta 1
  • lacking the SAM motif, type II isozyme containing a pleckstrin homology domain at the amino terminus
  • rapidly relocated back to the cytoplasm upon removal of stress stimuli
  • 30 - 4248 135 1220 testis, colon, kidney Murakami (2003)
  • also known as DGK eta 2
  • sterile alpha motif (SAM) domain added at the carboxyl terminus
  • exhibited sustained endosomal association
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic diacetylglycerol kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    text translocated from cytoplasm to endosomes, in response to stress stimuli mediated by the SAM domain
    basic FUNCTION
  • converting diacylglycerol to phosphatidic acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by phorboester (isoform 1)
    repressed by glycocorticoids (isoform 2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to bipolar disorder
    Variant & Polymorphism other a marker within the first intron strongly associated to bipolar disorder (Baum 2008)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS