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FLASH GENE

Symbol

DGAT2

contributors: mct - updated : 09-06-2015

HGNC name	diacylglycerol O-acyltransferase homolog 2 (mouse)
HGNC id	16940

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in psoriatic skin constitutional     --over   plays an important role in the pathogenesis of alcoholic fatty liver disease, and abnormal methionine metabolism contributes, at least partially, to DGAT2 upregulation via suppression of MEK/ERK1/2 activation

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice overexpressing hepatic Dgat2 fed a high-fat diet develop fatty liver, but not insulin resistance, suggesting that DGAT2 induces a dissociation between fatty liver and insulin resistance