Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

MUC5B

contributors: mct - updated : 20-02-2012

HGNC name	mucin 5, subtype B, tracheobronchial
HGNC id	7516

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function activated in gastric cancer (highly active distal promoter, upregulated by protein kinase C and repressed under the influence of methylation) constitutional     --over   in the airways of individuals with chronic respiratory diseases constitutional     --over   in chronic rhinosinusitis (CRS)

Susceptibility

to familial interstitial pneumonia and idiopathic pulmonary fibrosis

Variant & Polymorphism other	a common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis

Candidate gene
Marker	a long rare MUC5B-MS6 alleles could be used to identify the risk of bladder cancer
Therapy target

ANIMAL & CELL MODELS