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FLASH GENE

Symbol

MUC5B

contributors: mct - updated : 20-02-2012

HGNC name	mucin 5, subtype B, tracheobronchial
HGNC id	7516

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002458 47 - 17916 - 5762 - 2011 21619869

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth           salivary gland submaxillary       Reproductive female system uterus cervix     respiratory lung bronchi       Respiratory respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory alveolar epithelium

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	tandem repeats interrupted by cysteine-rich subdomains (TIL)
	three Von Willebrand factor type C domain
	four Von Willebrand factor type D domain
	cystine-Knot domain at the C terminus

HOMOLOGY

interspecies

homolog to murine Muc5b

intraspecies

homolog to MUC5AC,highly

Homologene

FAMILY

CATEGORY

secretory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	contributing to the lubricating and viscoelastic properties of whole saliva
	possible involvement of MUC5B gene in panbronchiolitis
	MUC5AC and MUC5B may play an important role in the pathogenesis of chronic rhinosinusitis and nasal polyposis
	major mucin in the gel phase of sputum in chronic obstructive pulmonary disease
	contribute to the viscoelastic properties of mucus
	PRKAB1-induced MUC5B expression may be regulated through the MAPK14 signaling pathway in human airway epithelial cells
	major airway mucin

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	NRG1beta1 is a novel mediator of MUC5AC and MUC5B expression in bronchial epithelial cells
	IGF1 constitutes the pathogenic factor in formation of nasal polyps and the regulatory factor in expression of mucins
	IGF1 induced MUC8 and MUC5B expression is regulated by activation of the ERK1 and MAPK14 signaling pathway in human airway epithelial cells

cell & other

REGULATION

activated by

LEP (leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway)

induced by	agonists of TRPV1 and TRPA1 induced MUC5B release in the nasal airways
		PRKAB1, that induced MUC5B expression
		IGF1 (IGF1 induced MUC8 and MUC5B expression, and activated phosphorylation of ERK1/2 and MAPK14)

Other	regulated by PTGDR, that may have suppressive effects in controlling MUC5B overproduction in the airway

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function activated in gastric cancer (highly active distal promoter, upregulated by protein kinase C and repressed under the influence of methylation) constitutional     --over   in the airways of individuals with chronic respiratory diseases constitutional     --over   in chronic rhinosinusitis (CRS)

Susceptibility

to familial interstitial pneumonia and idiopathic pulmonary fibrosis

Variant & Polymorphism other	a common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis

Candidate gene
Marker	a long rare MUC5B-MS6 alleles could be used to identify the risk of bladder cancer
Therapy target

ANIMAL & CELL MODELS