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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

DEF6

contributors: mct - updated : 14-03-2023

HGNC name	differentially expressed in FDCP 6 homolog (mouse)
HGNC id	2760

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IMD87

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   significantly correlated with a poor prognosis for patients with Clear cell renal cell carcinoma (ccRCC)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed osteoarticular bone ostéoporosis Def6-dependent pathway may represent a novel therapeutic target to prevent pathological bone destruction

ANIMAL & CELL MODELS

enhanced bone resorption in Def6-/- mice dominates, leading to osteoporosis